Visual scanning and cognitive performance in prediagnostic and early‐stage Huntington's disease
Identifieur interne : 001F88 ( Main/Exploration ); précédent : 001F87; suivant : 001F89Visual scanning and cognitive performance in prediagnostic and early‐stage Huntington's disease
Auteurs : Tanya Blekher [États-Unis] ; Marjorie R. Weaver [États-Unis] ; Jeanine Marshall [États-Unis] ; Siu Hui [États-Unis] ; Jacqueline Gray Jackson [États-Unis] ; Julie C. Stout [États-Unis, Australie] ; Xabier Beristain [États-Unis] ; Joanne Wojcieszek [États-Unis] ; Robert D. Yee [États-Unis] ; Tatiana M. Foroud [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-03-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Early stage, Eye Movements (physiology), Eye movement, Female, Humans, Huntington Disease (complications), Huntington Disease (diagnosis), Huntington Disease (genetics), Huntington disease, Huntington's disease, Linear Models, Male, Middle Aged, Nervous system diseases, Performance, Psychomotor Performance (physiology), Scanning, Spectrum Analysis (methods), Visual Pathways (physiopathology), Visual Perception, cognitive performance, digit symbol subscale, eye movement, visual scanning.
- MESH :
- complications : Huntington Disease.
- diagnosis : Cognition Disorders, Huntington Disease.
- etiology : Cognition Disorders.
- genetics : Huntington Disease.
- methods : Spectrum Analysis.
- physiology : Eye Movements, Psychomotor Performance.
- physiopathology : Visual Pathways.
- Adult, Analysis of Variance, Female, Humans, Linear Models, Male, Middle Aged, Visual Perception.
Abstract
The objective of this study was to evaluate visual scanning strategies in carriers of the Huntington disease (HD) gene expansion and to test whether there is an association between measures of visual scanning and cognitive performance. The study sample included control (NC, n = 23), prediagnostic (PDHD, n = 21), and subjects recently diagnosed with HD (HD, n = 19). All participants completed a uniform clinical evaluation that included examination by neurologist and molecular testing. Eye movements were recorded during completion of the Digit Symbol Subscale (DS) test. Quantitative measures of the subject's visual scanning were evaluated using joint analysis of eye movements and performance on the DS test. All participants employed a simple visual scanning strategy when completing the DS test. There was a significant group effect and a linear trend of decreasing frequency and regularity of visual scanning from NC to PDHD to HD. The performance of all groups improved slightly and in a parallel fashion across the duration of the DS test. There was a strong correlation between visual scanning measures and the DS cognitive scores. While all individuals employed a similar visual scanning strategy, the visual scanning measures grew progressively worse from NC to PDHD to HD. The deficits in visual scanning accounted, at least in part, for the decrease in the DS score. © 2008 Movement Disorder Society
Url:
- https://api.istex.fr/document/AAE4119253CC5D9AD5DF1DFD81E009F4E4E70999/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834211
DOI: 10.1002/mds.22329
Affiliations:
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Le document en format XML
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Weaver</name></author><author><name sortKey="Marshall, Jeanine" sort="Marshall, Jeanine" uniqKey="Marshall J" first="Jeanine" last="Marshall">Jeanine Marshall</name></author><author><name sortKey="Hui, Siu" sort="Hui, Siu" uniqKey="Hui S" first="Siu" last="Hui">Siu Hui</name></author><author><name sortKey="Jackson, Jacqueline Gray" sort="Jackson, Jacqueline Gray" uniqKey="Jackson J" first="Jacqueline Gray" last="Jackson">Jacqueline Gray Jackson</name></author><author><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. 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Weaver</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Marshall, Jeanine" sort="Marshall, Jeanine" uniqKey="Marshall J" first="Jeanine" last="Marshall">Jeanine Marshall</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Hui, Siu" sort="Hui, Siu" uniqKey="Hui S" first="Siu" last="Hui">Siu Hui</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Jackson, Jacqueline Gray" sort="Jackson, Jacqueline Gray" uniqKey="Jackson J" first="Jacqueline Gray" last="Jackson">Jacqueline Gray Jackson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. Stout</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology, Psychiatry, and Psychological Medicine, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Beristain, Xabier" sort="Beristain, Xabier" uniqKey="Beristain X" first="Xabier" last="Beristain">Xabier Beristain</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Wojcieszek, Joanne" sort="Wojcieszek, Joanne" uniqKey="Wojcieszek J" first="Joanne" last="Wojcieszek">Joanne Wojcieszek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Yee, Robert D" sort="Yee, Robert D" uniqKey="Yee R" first="Robert D." last="Yee">Robert D. Yee</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15">2009-03-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="533">533</biblScope><biblScope unit="page" to="540">540</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AAE4119253CC5D9AD5DF1DFD81E009F4E4E70999</idno><idno type="DOI">10.1002/mds.22329</idno><idno type="ArticleID">MDS22329</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Early stage</term><term>Eye Movements (physiology)</term><term>Eye movement</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (genetics)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Performance</term><term>Psychomotor Performance (physiology)</term><term>Scanning</term><term>Spectrum Analysis (methods)</term><term>Visual Pathways (physiopathology)</term><term>Visual Perception</term><term>cognitive performance</term><term>digit symbol subscale</term><term>eye movement</term><term>visual scanning</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Spectrum Analysis</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Eye Movements</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Visual Pathways</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Visual Perception</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Balayage</term><term>Chorée de Huntington</term><term>Mouvement oculaire</term><term>Pathologie du système nerveux</term><term>Performance</term><term>Stade précoce</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to evaluate visual scanning strategies in carriers of the Huntington disease (HD) gene expansion and to test whether there is an association between measures of visual scanning and cognitive performance. The study sample included control (NC, n = 23), prediagnostic (PDHD, n = 21), and subjects recently diagnosed with HD (HD, n = 19). All participants completed a uniform clinical evaluation that included examination by neurologist and molecular testing. Eye movements were recorded during completion of the Digit Symbol Subscale (DS) test. Quantitative measures of the subject's visual scanning were evaluated using joint analysis of eye movements and performance on the DS test. All participants employed a simple visual scanning strategy when completing the DS test. There was a significant group effect and a linear trend of decreasing frequency and regularity of visual scanning from NC to PDHD to HD. The performance of all groups improved slightly and in a parallel fashion across the duration of the DS test. There was a strong correlation between visual scanning measures and the DS cognitive scores. While all individuals employed a similar visual scanning strategy, the visual scanning measures grew progressively worse from NC to PDHD to HD. The deficits in visual scanning accounted, at least in part, for the decrease in the DS score. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Blekher, Tanya" sort="Blekher, Tanya" uniqKey="Blekher T" first="Tanya" last="Blekher">Tanya Blekher</name></region><name sortKey="Beristain, Xabier" sort="Beristain, Xabier" uniqKey="Beristain X" first="Xabier" last="Beristain">Xabier Beristain</name><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name><name sortKey="Hui, Siu" sort="Hui, Siu" uniqKey="Hui S" first="Siu" last="Hui">Siu Hui</name><name sortKey="Jackson, Jacqueline Gray" sort="Jackson, Jacqueline Gray" uniqKey="Jackson J" first="Jacqueline Gray" last="Jackson">Jacqueline Gray Jackson</name><name sortKey="Marshall, Jeanine" sort="Marshall, Jeanine" uniqKey="Marshall J" first="Jeanine" last="Marshall">Jeanine Marshall</name><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. Stout</name><name sortKey="Weaver, Marjorie R" sort="Weaver, Marjorie R" uniqKey="Weaver M" first="Marjorie R." last="Weaver">Marjorie R. Weaver</name><name sortKey="Wojcieszek, Joanne" sort="Wojcieszek, Joanne" uniqKey="Wojcieszek J" first="Joanne" last="Wojcieszek">Joanne Wojcieszek</name><name sortKey="Yee, Robert D" sort="Yee, Robert D" uniqKey="Yee R" first="Robert D." last="Yee">Robert D. Yee</name></country><country name="Australie"><noRegion><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. Stout</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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